ABSTRACT
ABSTRACT The aim of this study was to investigate the effect of gels containing the monoterpene borneol in induced oral mucositis using an animal model. Gels were prepared with borneol at 1.2% and 2.4% (w/w). Oral mucositis was induced by administration of three doses of 5-fluorouracil (30 mg/kg, i.p.) and injury with acetic acid (50%, v/v) soaked in filter paper applied to right cheek mucosa for 60s. Four subgroups comprising 12 animals each were formed. Six animals from each group were sacrificed at days seven and fourteen after oral mucositis induction. Mucous samples were processed and stained with hematoxylin-eosin and Masson's Trichrome. The semiquantitative evaluation involved observation of inflammatory parameters. ImageJ® software was used in the quantitative evaluation. For statistical analyses, Two-way ANOVA, followed by Tukey's post-test (p <0.05), were employed. Borneol 2.4% gel proved effective in the treatment of oral mucositis with statistically significant differences between groups for angiogenesis control, inflammatory cell count reduction and percentage neoformed collagen increase. The confirmation of anti-inflammatory and healing action of borneol in oral mucositis in rats renders it a good marker for predicting this activity for plant extracts rich in this substance
Subject(s)
Animals , Male , Rats , Stomatitis , Monoterpenes/adverse effects , Gels/adverse effects , Anti-Inflammatory Agents , Software/ethics , Plant Extracts/agonists , Hypericum/classificationABSTRACT
El proceso de elaboración de un software educativo es una actividad que requiere de la participación de diferentes ciencias para la obtención de un resultado con calidad, o sea de la interdisciplinaridad. Al respecto, el grupo investigación-acción del Proyecto nacional para la producción de software educativo (SE) en la Educación Médica Superior, Galenomedia, durante sus más de seis años de trabajo, identificó que los aspectos más analizados en proyectos de investigación, publicaciones y tesis de maestría que abordan la elaboración de un software educativo, están relacionados con la Informática, la pedagogía y la ciencia en cuestión, dejando al margen frecuentemente el análisis de los aspectos éticos que también marcan pautas importantes en su desarrollo. El presente trabajo pretende reflexionar sobre algunos principios éticos que deben ser considerados en la elaboración y uso del software educativo en el campo de la salud con el objetivo de contribuir a perfeccionar su proceso de elaboración y con ello a una mejor formación de los profesionales de la salud
The process of creation of educational software requires the involvement of several sciences to achieve a quality result, that is, requires interdisciplinarity. In over six years of work, the research/action group of the national project for the production of educational software in the higher medical education, known as Galenomedia, found out that the most analyzed aspects in educational software-linked research projects, publications and Master of Sciences' theses had been informatics, pedagogy and sciences; however, the analysis of ethical aspects that may also establish important guidelines for the development of this type of software had been frequently neglected. The present paper was intended to make reflections on some of the ethical principles that should be borne in mind in creating and using educational software in the field of health care, in order to support the improvement of this process and the better formation of health professionals